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PUMCH Zhang Fengchun's team reveals a new mechanism for abnormal B cell activation in primary Sjogren’s syndrome
CopyFrom: PUMCH UpdateTime: 2020-11-20 Hits: 327 Font Size: SmallBig

The research team led by Professor Zhang Fengchun from the Department of Rheumatology and Immunology of PUMCH explored the gene expression profile of primary Sjogren’s syndrome (pSS) B cells and discovered the expression of epithelial matrix interacting protein 1 (EPSTI1), and revealed for the first time that this protein regulates abnormal B cell activation Mechanisms. The results of this research were published in one of the top journals Annals of the Rheumatic Diseases, the team from the Department of Rheumatology and Immunology of PUMCH has once again achieved breakthrough scientific research results in the pathogenesis of rheumatism.


▲The B cells of primary Sjogren’s syndrome express abnormally high EPSTI1.

Professor Zhang Fengchun concluded that starting from the clinic, discovering scientific problems and conducting translational medicine research are the advantages of clinical medical workers with abundant case resources in scientific research.

Photo by/ Department of Rheumatology and Immunology