鞠斌
独立PI、中国医学科学院北京协和医学院准聘副教授 博士研究生导师 博士后合作导师
研究领域：
感染与免疫，抗病毒中和抗体
既往成果：
主要从事抗病毒中和抗体研究，紧密围绕病毒感染与抗体中和的几个博弈阶段，系统阐明了抗体如何对抗病毒感染及其发挥作用的分子机制。以第一/通讯作者（含共同）发表SCI论文30余篇，包括Cell, Nature, Nat Immunol, Immunity（封面）, Gut, PLoS Pathog, Cell Res（2篇）, Cell Rep（3篇）, Sci Adv, Nat Commun（5篇）, J Virol（2篇）, J Immunol（封面）等；以共同发明人授权专利10余项，获批新冠病毒中和抗体联合药物安巴韦单抗注射液和罗米司韦单抗注射液；先后主持国自然优秀青年基金、国自然重大研究计划集成项目、国家科技重大专项课题、国自然面上项目、国自然青年项目、广东省杰出青年基金、深圳市优秀青年基金等10余项；曾获得中国免疫学会青年学者奖、深圳市青年科技奖、深圳市国家级领军人才、深圳市抗击新冠肺炎疫情先进个人、深圳青年五四奖章、中华医学科技二等奖、深圳市科技进步二等奖、华夏医学科技三等奖等10余项。
近5年代表性论著（第一/通讯）
（1）Ju Bin(#)(*), Liu Congcong(#), Zhang Jingjing(#), Li Yaning(#), Yang Haonan(#), Zhou Bing(#), Huang Baoying(#), Ma Jianrong, Lu Jiahan, Cheng Lin, Cong Zhe, Zhu Lin, Shi Tianhao, Sun Yuehong, Li Na, Chen Ting, Wang Miao, Tang Shilong, Ge Xiangyang, Zhao Juanjuan, Tan Wen-Jie(*), Yan Renhong(*), Xue Jing(*), Zhang Zheng(*). Structurally conserved human anti-A35 antibodies protect mice and macaques from mpox virus infection. Cell, 2025, 188(22):6253-6265. 中科院分区: 生物学1区, 5年影响因子: 48.9
（2）Ju Bin(#), Zhang Qi(#), Ge Jiwan(#), Wang Ruoke, Sun Jing, Ge Xiangyang, Yu Jiazhen, Shan Sisi, Zhou Bing, Song Shuo, Tang Xian, Yu Jinfang, Lan Jun, Yuan Jing, Wang Haiyan, Zhao Juanjuan, Zhang Shuye, Wang Youchun, Shi Xuanling, Liu Lei, Zhao Jincun, Wang Xinquan(*), Zhang Zheng(*), Zhang Linqi(*). Human neutralizing antibodies elicited by SARS-CoV-2 infection. Nature, 2020, 584(7819):115-119. 中科院分区: 综合1区, 5年影响因子: 54.4
（3）Ju Bin(#), Zhang Qi(#), Wang Ziyi(#), Aw Zhen Qin(#), Chen Peng(#), Zhou Bing, Wang Ruoke, Ge Xiangyang, Lv Qining, Cheng Lin, Zhang Rui, Wong Yi Hao, Chen Huixin, Wang Haiyan, Shan Sisi, Liao Xuejiao, Shi Xuanling, Liu Lei, Chu Justin Jang Hann(*), Wang Xinquan(*), Zhang Zheng(*), Zhang Linqi(*). Infection with wild-type SARS-CoV-2 elicits broadly neutralizing and protective antibodies against omicron subvariants. Nature Immunology, 2023, 24(4):690-699. 中科院分区: 医学1区, 5年影响因子: 28.3
（4）Ju Bin(#)(*), Liu Zhouqing(#), Yan Hu(#), Liu Yong(#), Zhang Lu(#), Ge Xiangyang(#), Wang Xin(#), Si Zhu, Zhou Bing, Fan Qing, Wang Miao, Li Yuxiao, Lai Wenlong, Gan Jianhui, Wang Haiyan, Zhao Juanjuan, Xia Yuchen(*), Liao Maofu(*), Zhang Zheng(*). Characterisation of plasmablast-derived HBsAg-specific antibody and its structural basis for binding to native HBsAg dimer. Gut, 2026, doi: 10.1136/gutjnl-2025-336641. 中科院分区: 医学1区, 5年影响因子: 25.3
（5）Ju Bin(#)(*), Fan Qing(#), Liu Congcong(#), Shen Senlin(#), Wang Miao(#), Guo Huimin, Zhou Bing, Ge Xiangyang, Zhang Zheng(*). Omicron BQ.1.1 and XBB.1 unprecedentedly escape broadly neutralizing antibodies elicited by prototype vaccination. Cell Reports, 2023, 42(6):112532. 中科院分区: 生物学1区, 5年影响因子: 8.5
（6）Ju Bin(#)(*), Fan Qing(#), Wang Miao(#), Liao Xuejiao, Guo Huimin, Wang Haiyan, Ge Xiangyang, Liu Lei, Zhang Zheng(*). Antigenic sin of wild-type SARS-CoV-2 vaccine shapes poor cross-neutralization of BA.4/5/2.75 subvariants in BA.2 breakthrough infections. Nature Communications, 2022, 13(1):7120. 中科院分区: 综合1区, 5年影响因子: 16.1
（7）Li Wenting(#), Liu Congcong(#), Li Yaning(#), Gui Qi(#), Cheng Lin, Fan Qing, Zhou Bing, Wang Haiyan, Ge Xiangyang, Zhang Zheng(*), Yan Renhong(*), Ju Bin(*). A SARS-CoV-2 variant-induced NTD-targeting antibody enhances viral infection via a distinctive binding mode. PLoS Pathogens, 2026, 22(2):e1013828. 中科院分区: 医学1区, 5年影响因子: 5.4
（8）Yan Hu(#), Liu Congcong(#), Li Yuxiao(#), Tang Shilong, Guo Huimin, Zhou Bing, Fan Qing, Wang Haiyan, Ge Xiangyang, Wang Xin, Liao Xuejiao, Li Jin, Zhang Zheng(*), Ju Bin(*). The characterization and structural basis of a human broadly binding antibody to HBV core protein. Journal of Virology, 2025, 99(1):e0169424. 中科院分区: 病毒学1区, 5年影响因子: 4.0
（9）Zhou Bing(#), Gui Qi(#), Liu Congcong(#), Guo Huimin(#), Wang Haiyan, Cheng Lin, Fan Qing, Ge Xiangyang, Zhang Zheng(*), Ju Bin(*). Structure and function of an unusual R452-dependent monoclonal antibody against SARS-CoV-2. Journal of Virology, 2025, 99(5):e0184424. 中科院分区: 病毒学1区, 5年影响因子: 4.0
（10）Wang Miao(#), Liu Congcong(#), Fan Qing(#), Sun Yuehong(#), Tang Shilong, Guo Huimin, Zhou Bing, Wang Haiyan, Ge Xiangyang, Zhang Zheng(*), Ju Bin(*). Rapid clonal expansion and somatic hypermutation contribute to the fate of SARS-CoV-2 broadly neutralizing antibodies. Journal of Immunology. 2025, 214(2):278-289. 中科院分区: 医学3区, 5年影响因子: 4.2 (封面文章)
近5年代表性论著（第一/通讯）
（1）Ju Bin(#)(*), Liu Congcong(#), Zhang Jingjing(#), Li Yaning(#), Yang Haonan(#), Zhou Bing(#), Huang Baoying(#), Ma Jianrong, Lu Jiahan, Cheng Lin, Cong Zhe, Zhu Lin, Shi Tianhao, Sun Yuehong, Li Na, Chen Ting, Wang Miao, Tang Shilong, Ge Xiangyang, Zhao Juanjuan, Tan Wen-Jie(*), Yan Renhong(*), Xue Jing(*), Zhang Zheng(*). Structurally conserved human anti-A35 antibodies protect mice and macaques from mpox virus infection. Cell, 2025, 188(22):6253-6265. 中科院分区: 生物学1区, 5年影响因子: 48.9
（2）Ju Bin(#), Zhang Qi(#), Ge Jiwan(#), Wang Ruoke, Sun Jing, Ge Xiangyang, Yu Jiazhen, Shan Sisi, Zhou Bing, Song Shuo, Tang Xian, Yu Jinfang, Lan Jun, Yuan Jing, Wang Haiyan, Zhao Juanjuan, Zhang Shuye, Wang Youchun, Shi Xuanling, Liu Lei, Zhao Jincun, Wang Xinquan(*), Zhang Zheng(*), Zhang Linqi(*). Human neutralizing antibodies elicited by SARS-CoV-2 infection. Nature, 2020, 584(7819):115-119. 中科院分区: 综合1区, 5年影响因子: 54.4
（3）Ju Bin(#), Zhang Qi(#), Wang Ziyi(#), Aw Zhen Qin(#), Chen Peng(#), Zhou Bing, Wang Ruoke, Ge Xiangyang, Lv Qining, Cheng Lin, Zhang Rui, Wong Yi Hao, Chen Huixin, Wang Haiyan, Shan Sisi, Liao Xuejiao, Shi Xuanling, Liu Lei, Chu Justin Jang Hann(*), Wang Xinquan(*), Zhang Zheng(*), Zhang Linqi(*). Infection with wild-type SARS-CoV-2 elicits broadly neutralizing and protective antibodies against omicron subvariants. Nature Immunology, 2023, 24(4):690-699. 中科院分区: 医学1区, 5年影响因子: 28.3
（4）Ju Bin(#)(*), Liu Zhouqing(#), Yan Hu(#), Liu Yong(#), Zhang Lu(#), Ge Xiangyang(#), Wang Xin(#), Si Zhu, Zhou Bing, Fan Qing, Wang Miao, Li Yuxiao, Lai Wenlong, Gan Jianhui, Wang Haiyan, Zhao Juanjuan, Xia Yuchen(*), Liao Maofu(*), Zhang Zheng(*). Characterisation of plasmablast-derived HBsAg-specific antibody and its structural basis for binding to native HBsAg dimer. Gut, 2026, doi: 10.1136/gutjnl-2025-336641. 中科院分区: 医学1区, 5年影响因子: 25.3
（5）Ju Bin(#)(*), Fan Qing(#), Liu Congcong(#), Shen Senlin(#), Wang Miao(#), Guo Huimin, Zhou Bing, Ge Xiangyang, Zhang Zheng(*). Omicron BQ.1.1 and XBB.1 unprecedentedly escape broadly neutralizing antibodies elicited by prototype vaccination. Cell Reports, 2023, 42(6):112532. 中科院分区: 生物学1区, 5年影响因子: 8.5
（6）Ju Bin(#)(*), Fan Qing(#), Wang Miao(#), Liao Xuejiao, Guo Huimin, Wang Haiyan, Ge Xiangyang, Liu Lei, Zhang Zheng(*). Antigenic sin of wild-type SARS-CoV-2 vaccine shapes poor cross-neutralization of BA.4/5/2.75 subvariants in BA.2 breakthrough infections. Nature Communications, 2022, 13(1):7120. 中科院分区: 综合1区, 5年影响因子: 16.1
（7）Li Wenting(#), Liu Congcong(#), Li Yaning(#), Gui Qi(#), Cheng Lin, Fan Qing, Zhou Bing, Wang Haiyan, Ge Xiangyang, Zhang Zheng(*), Yan Renhong(*), Ju Bin(*). A SARS-CoV-2 variant-induced NTD-targeting antibody enhances viral infection via a distinctive binding mode. PLoS Pathogens, 2026, 22(2):e1013828. 中科院分区: 医学1区, 5年影响因子: 5.4
（8）Yan Hu(#), Liu Congcong(#), Li Yuxiao(#), Tang Shilong, Guo Huimin, Zhou Bing, Fan Qing, Wang Haiyan, Ge Xiangyang, Wang Xin, Liao Xuejiao, Li Jin, Zhang Zheng(*), Ju Bin(*). The characterization and structural basis of a human broadly binding antibody to HBV core protein. Journal of Virology, 2025, 99(1):e0169424. 中科院分区: 病毒学1区, 5年影响因子: 4.0
（9）Zhou Bing(#), Gui Qi(#), Liu Congcong(#), Guo Huimin(#), Wang Haiyan, Cheng Lin, Fan Qing, Ge Xiangyang, Zhang Zheng(*), Ju Bin(*). Structure and function of an unusual R452-dependent monoclonal antibody against SARS-CoV-2. Journal of Virology, 2025, 99(5):e0184424. 中科院分区: 病毒学1区, 5年影响因子: 4.0
（10）Wang Miao(#), Liu Congcong(#), Fan Qing(#), Sun Yuehong(#), Tang Shilong, Guo Huimin, Zhou Bing, Wang Haiyan, Ge Xiangyang, Zhang Zheng(*), Ju Bin(*). Rapid clonal expansion and somatic hypermutation contribute to the fate of SARS-CoV-2 broadly neutralizing antibodies. Journal of Immunology. 2025, 214(2):278-289. 中科院分区: 医学3区, 5年影响因子: 4.2 (封面文章)