栾晓东
药物研发与评价平台 主任
研究领域：
结构药理学
既往成果：
中国生物物理学会会员、中国细胞生物学会会员，Science Bulletin等杂志审稿人，目前已发表研究论文10余篇，其中共一作文章包括1篇Science、1篇Nature、1篇NSMB等，总被引1000余次，2 篇论文被Faculty of 1000 推荐评论，2 篇论文入选ESI 高被引论文（Highly Cited Paper, Top 1%）。研究成果瑞德西韦抑制新冠病毒RdRp的作用机制入选2020年中科院“率先行动”计划第一阶段重大科技成果。解析的新冠病毒RdRp 结合RNA 和瑞德西韦的复合体冷冻电镜结构被蛋白质结构数据库（ProteinData Bank，PDB）选为2020 年9 月的明星分子（September Molecule of the Month）。
[1] Xiaodong Luan#, Binxian Chen#, Weijuan Shang#, Wanchao Yin, Ye Jin, Leike Zhang*, H.Eric Xu*, Shuyang Zhang*. (2022). Structure basis for inhibition of SARS-CoV-2 by the feline drug GC376. Acta Pharmacologica Sinica. 44, 255–257 (2023). https://doi.org/10.1038/s41401-022-00929-z
[2] Xiaodong Luan#, Xinming Li#, Yufan Li#, Gengchen Su#, Wanchao Yin, Yi Jiang, Ning Xu, Feng Wang, Wang Cheng, Ye Jin, Leike Zhang, H.Eric Xu*, Yi Xue* and Shuyang Zhang*. (2022). Structural Insights into NTD and CTD of SARS-CoV-2 nucleocapsid protein Underlies Their Perspectives for Antiviral Drug Design. Science Bulletin. 2022 Nov 30;67(22):2327-2335. doi: 10.1016/j.scib.2022.10.021.
[3] Jia Duan#, Peiyu Xu#, Xiaodong Luan#, Yujie ji, Xinheng He, Ning Song, Qingning Yuan, Ye Jin, Xi Cheng, Hualiang Jiang, Jie Zhang, Shuyang Zhang*, Yi Jiang* and H.Eric Xu*. (2022). Hormone- and antibody-mediated activation of the thyrotropin receptor. Nature. 609, 854–859 (2022). https://doi.org/10.1038/s41586-022-05173-3.
[4] Wanchao Yin#, Xiaodong Luan#, Zhihai Li#, Ziwei Zhou#, Qingxing Wang#, Minqi Gao, Xiaoxi Wang, Fulai Zhou, Jingjing Shi, Erli You, Mingliang Liu, Qingxia Wang, Yi Jiang, Hualiang Jiang, Gengfu Xiao, Leike Zhang*, , Xuekui Yu*, Shuyang Zhang*and H.Eric Xu*. (2021). Structural basis for inhibition of the SARS-CoV-2 RNA polymerase by suramin. Nature Structural & Molecular Biology. 2021 Mar;28(3):319-325.doi: 10.1038/s41594-021-00570-0.
[5] Wanchao Yin#, Chunyou Mao#, Xiaodong Luan#, Dandan Shen#, Qingya Shen#, Haixia Su#, Xiaoxi Wang, Fulai Zhou, Wenfeng Zhao, Minqi Gao, Shenghai Chang, Yuanchao Xie, Guanghui Tian, Hewei Jiang, Shengce Tao, Jingshan Shen, Yi Jiang, Hualiang Jiang, Yechun Xu*, Shuyang Zhang*, Yan Zhang* and H.Eric Xu*. (2020). Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir. Science. 2020 Jun 26;368(6498):1499-1504.doi: 10.1126/science.abc1560.
[6] Jia Duan#, Peiyu Xu#, Huibing Zhang#, Xiaodong Luan#, Jiaqi Yang, Xinheng He, Chunyou Mao, Dandan Shen, Yujie Ji, Xi Cheng, Hualiang Jiang, Yi Jiang, Shuyang Zhang*, Yan Zhang* and H.Eric Xu*. (2023). Universal mechanism of hormone and allosteric agonist mediated activation of glycoprotein hormone receptors as revealed by structures of follcle stimulating hormone receptor. Nature Communications . 2023 Jan 31;14(1):519.doi: 10.1038/s41467-023-36170-3.
[1] Xiaodong Luan#, Binxian Chen#, Weijuan Shang#, Wanchao Yin, Ye Jin, Leike Zhang*, H.Eric Xu*, Shuyang Zhang*. (2022). Structure basis for inhibition of SARS-CoV-2 by the feline drug GC376. Acta Pharmacologica Sinica. 44, 255–257 (2023). https://doi.org/10.1038/s41401-022-00929-z
[2] Xiaodong Luan#, Xinming Li#, Yufan Li#, Gengchen Su#, Wanchao Yin, Yi Jiang, Ning Xu, Feng Wang, Wang Cheng, Ye Jin, Leike Zhang, H.Eric Xu*, Yi Xue* and Shuyang Zhang*. (2022). Structural Insights into NTD and CTD of SARS-CoV-2 nucleocapsid protein Underlies Their Perspectives for Antiviral Drug Design. Science Bulletin. 2022 Nov 30;67(22):2327-2335. doi: 10.1016/j.scib.2022.10.021.
[3] Jia Duan#, Peiyu Xu#, Xiaodong Luan#, Yujie ji, Xinheng He, Ning Song, Qingning Yuan, Ye Jin, Xi Cheng, Hualiang Jiang, Jie Zhang, Shuyang Zhang*, Yi Jiang* and H.Eric Xu*. (2022). Hormone- and antibody-mediated activation of the thyrotropin receptor. Nature. 609, 854–859 (2022). https://doi.org/10.1038/s41586-022-05173-3.
[4] Wanchao Yin#, Xiaodong Luan#, Zhihai Li#, Ziwei Zhou#, Qingxing Wang#, Minqi Gao, Xiaoxi Wang, Fulai Zhou, Jingjing Shi, Erli You, Mingliang Liu, Qingxia Wang, Yi Jiang, Hualiang Jiang, Gengfu Xiao, Leike Zhang*, , Xuekui Yu*, Shuyang Zhang*and H.Eric Xu*. (2021). Structural basis for inhibition of the SARS-CoV-2 RNA polymerase by suramin. Nature Structural & Molecular Biology. 2021 Mar;28(3):319-325.doi: 10.1038/s41594-021-00570-0.
[5] Wanchao Yin#, Chunyou Mao#, Xiaodong Luan#, Dandan Shen#, Qingya Shen#, Haixia Su#, Xiaoxi Wang, Fulai Zhou, Wenfeng Zhao, Minqi Gao, Shenghai Chang, Yuanchao Xie, Guanghui Tian, Hewei Jiang, Shengce Tao, Jingshan Shen, Yi Jiang, Hualiang Jiang, Yechun Xu*, Shuyang Zhang*, Yan Zhang* and H.Eric Xu*. (2020). Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir. Science. 2020 Jun 26;368(6498):1499-1504.doi: 10.1126/science.abc1560.
[6] Jia Duan#, Peiyu Xu#, Huibing Zhang#, Xiaodong Luan#, Jiaqi Yang, Xinheng He, Chunyou Mao, Dandan Shen, Yujie Ji, Xi Cheng, Hualiang Jiang, Yi Jiang, Shuyang Zhang*, Yan Zhang* and H.Eric Xu*. (2023). Universal mechanism of hormone and allosteric agonist mediated activation of glycoprotein hormone receptors as revealed by structures of follcle stimulating hormone receptor. Nature Communications . 2023 Jan 31;14(1):519.doi: 10.1038/s41467-023-36170-3.