张现忠
平台主任 教授
研究领域：
分子影像、放射性药物
既往成果：
张现忠博士于长期致力于放射性药物及核素标记的多功能分子探针基础与转化研究。在分子影像探针设计、合成、标记、体内外评价以及成像方法和临床转化等方面开展一系列研究。在JNM, EJNMMI, J Med Chem等本领域专业期刊发表SCI论文143篇；获授权发明专利 66项，其中3项第一发明人专利成果已获临床试验批件，分别用于肝功能、肿瘤和冠心病的早期诊断。主持科技部973课题1项，国家自然科学基金核技术联合创新重点项目、肿瘤演进可视化重大研究计划培育项目以及面上项目等30余项。曾获厦门市重点人才（2013）、第十二届福建青年科技奖（2014）、华夏医学科技奖三等奖（2021）和中华医学科学技术奖三等奖（2022）等奖励。入选科技部人才推进计划中青年科技创新领军人才和中组部国家高层次人才特殊支持计划（万人计划）科技创新领军人才（2020）、福建省级高层次人才A类（2021）。
张现忠博士担任国内外多种学术期刊编委会顾问、副编辑和编委等职。任中国化学会高级会员、中国核学会放射性药物分会常务理事、同位素分会理事等职。
学术论文（代表性论文，5-10篇）
1. Jianyang Fang#, Lixia Feng#, Lingxin Meng#, Xiaobo Wang, Huanhuan Liu, Lumei Huang, Deliang Zhang, Jingchao Li, Rongqiang Zhuang, Zhide Guo* and Xianzhong Zhang*. A Novel 18F-Labeled Agonist for PET Imaging of Stimulator of Interferon Genes Expression in Tumor-bearing Mice. Eur J Nucl Med Mol Imaging, 2022, 50, 27–37.
2. Jindian Li, Juno Van Valkenburgh, Jianyang Fang, Deliang Zhang, Yingxi Chen, Quan Chen, Guorong Jia, Austin Z. Chen, Xianzhong Zhang*, Kai Chen*. Development of a novel radiofluorinated riboflavin probe for riboflavin receptor-targeting PET imaging. Pharmacological Research, Volume 183, September 2022, 106395.
3. Xuejun Wen, Changrong Shi, Xinying Zeng, Liang Zhao, Lanlin Yao, Zhida Liu, Lixia Feng, Deliang Zhang, Jinxiong Huang, Yesen Li, Qin Lin, Haojun Chen, Rongqiang Zhuang, Xiaoyuan Chen*, Xianzhong Zhang*, Zhide Guo*. A paradigm of cancer immunotherapy based on 2-[18F]FDG and anti-PD-L1 mAb combination to enhance the anti-tumor effect. Clin Cancer Res. 2022 Jul 1;28(13):2923-2937.
4. Xuejun Wen, Changrong Shi, Liu Yang, Xinying Zeng, Xiaoru Lin, Jinxiong Huang, Yesen Li, Rongqiang Zhuang, Haibo Zhu, Zhide Guo* & Xianzhong Zhang*. A radioiodinated FR--targeted tracer with improved pharmacokinetics through modification with an albumin binder for imaging of macrophages in AS and NAFL, Eur J Nucl Med Mol Imaging, 2022. 49, pages503–516.
5. Xu, Duo#; Lin, Xiaoru#; Zeng, Xinying#; Wen, Xuejun; Li, Jingchao; Li, Yesen; Huang, Jinxiong; Chen, Xiaoyuan; Guo, Zhide*; Zhang, Xianzhong*. Radioiodinated 4-(p-iodophenyl) butanoic acid modified estradiol derivative for ER targeting SPECT imaging. Analytical Chemistry, 2021, 93, 41, 13998-14006.
6. Longguang Tang#, Chenyu Peng#, Bowen Tang, Zijing Li*, Xiangyu Wang, Jindian Li, Fei Gao, Lumei Huang, Duo Xu, Pu Zhang, Rongqiang Zhuang, Xinhui Su, Xiaoyuan Chen, and Xianzhong Zhang*. Radioiodinated Small Molecule Tyrosine Kinase Inhibitor for HER2 Selective SPECT Imaging. J Nucl Med 2018 59:1386-1391.
7. Pu Zhang,+ Rongqiang Zhuang,+ Zhide Guo, Xinhui Su, Xiaoyuan Chen,* and Xianzhong Zhang*. A Highly Efficient Copper-Mediated Radioiodination Approach Using Aryl Boronic Acids. Chemistry - A European Journal, 2016, 22, 16783-16786.
8. Zhide Guo, Mengna Gao, Manli Song, Yesen Li, Deliang Zhang, Duo Xu, Linyi You, Liangliang Wang, Rongqiang Zhuang, Xinhui Su, Ting Liu, Jin Du, Xianzhong Zhang*. Superfluorinated PEI Derivative Coupled with 99mTc for ASGPR Targeted 19F MRI/SPECT/PA Tri-Modality Imaging. Adv. Mater., 2016, 28, 5898–5906.
9. Tiantian Mou, Zuoquan Zhao, Wei Fang*, Cheng Peng, Feng Guo, Boli, Liu*, Yunchuan Ma, Xianzhong Zhang*. Synthesis and Preliminary Evaluation of 18F-labeled Pyridaben Analogues for Myocardial Perfusion Imaging with Positron Emission Tomography. J Nucl Med, 2012, 53(3): 472-479.
10. Xianzhong Zhang, Zhengming Xiong, Yun Wu, Weibo Cai, Jeffery R. Tseng, Sanjiv S. Gambhir and Xiaoyuan Chen*. Quantitative PET imaging of tumor integrin V3 expression with [18F]FRGD2. J Nucl Med, 2006, 47:113-121.
张现忠博士担任国内外多种学术期刊编委会顾问、副编辑和编委等职。任中国化学会高级会员、中国核学会放射性药物分会常务理事、同位素分会理事等职。
学术论文（代表性论文，5-10篇）
1. Jianyang Fang#, Lixia Feng#, Lingxin Meng#, Xiaobo Wang, Huanhuan Liu, Lumei Huang, Deliang Zhang, Jingchao Li, Rongqiang Zhuang, Zhide Guo* and Xianzhong Zhang*. A Novel 18F-Labeled Agonist for PET Imaging of Stimulator of Interferon Genes Expression in Tumor-bearing Mice. Eur J Nucl Med Mol Imaging, 2022, 50, 27–37.
2. Jindian Li, Juno Van Valkenburgh, Jianyang Fang, Deliang Zhang, Yingxi Chen, Quan Chen, Guorong Jia, Austin Z. Chen, Xianzhong Zhang*, Kai Chen*. Development of a novel radiofluorinated riboflavin probe for riboflavin receptor-targeting PET imaging. Pharmacological Research, Volume 183, September 2022, 106395.
3. Xuejun Wen, Changrong Shi, Xinying Zeng, Liang Zhao, Lanlin Yao, Zhida Liu, Lixia Feng, Deliang Zhang, Jinxiong Huang, Yesen Li, Qin Lin, Haojun Chen, Rongqiang Zhuang, Xiaoyuan Chen*, Xianzhong Zhang*, Zhide Guo*. A paradigm of cancer immunotherapy based on 2-[18F]FDG and anti-PD-L1 mAb combination to enhance the anti-tumor effect. Clin Cancer Res. 2022 Jul 1;28(13):2923-2937.
4. Xuejun Wen, Changrong Shi, Liu Yang, Xinying Zeng, Xiaoru Lin, Jinxiong Huang, Yesen Li, Rongqiang Zhuang, Haibo Zhu, Zhide Guo* & Xianzhong Zhang*. A radioiodinated FR--targeted tracer with improved pharmacokinetics through modification with an albumin binder for imaging of macrophages in AS and NAFL, Eur J Nucl Med Mol Imaging, 2022. 49, pages503–516.
5. Xu, Duo#; Lin, Xiaoru#; Zeng, Xinying#; Wen, Xuejun; Li, Jingchao; Li, Yesen; Huang, Jinxiong; Chen, Xiaoyuan; Guo, Zhide*; Zhang, Xianzhong*. Radioiodinated 4-(p-iodophenyl) butanoic acid modified estradiol derivative for ER targeting SPECT imaging. Analytical Chemistry, 2021, 93, 41, 13998-14006.
6. Longguang Tang#, Chenyu Peng#, Bowen Tang, Zijing Li*, Xiangyu Wang, Jindian Li, Fei Gao, Lumei Huang, Duo Xu, Pu Zhang, Rongqiang Zhuang, Xinhui Su, Xiaoyuan Chen, and Xianzhong Zhang*. Radioiodinated Small Molecule Tyrosine Kinase Inhibitor for HER2 Selective SPECT Imaging. J Nucl Med 2018 59:1386-1391.
7. Pu Zhang,+ Rongqiang Zhuang,+ Zhide Guo, Xinhui Su, Xiaoyuan Chen,* and Xianzhong Zhang*. A Highly Efficient Copper-Mediated Radioiodination Approach Using Aryl Boronic Acids. Chemistry - A European Journal, 2016, 22, 16783-16786.
8. Zhide Guo, Mengna Gao, Manli Song, Yesen Li, Deliang Zhang, Duo Xu, Linyi You, Liangliang Wang, Rongqiang Zhuang, Xinhui Su, Ting Liu, Jin Du, Xianzhong Zhang*. Superfluorinated PEI Derivative Coupled with 99mTc for ASGPR Targeted 19F MRI/SPECT/PA Tri-Modality Imaging. Adv. Mater., 2016, 28, 5898–5906.
9. Tiantian Mou, Zuoquan Zhao, Wei Fang*, Cheng Peng, Feng Guo, Boli, Liu*, Yunchuan Ma, Xianzhong Zhang*. Synthesis and Preliminary Evaluation of 18F-labeled Pyridaben Analogues for Myocardial Perfusion Imaging with Positron Emission Tomography. J Nucl Med, 2012, 53(3): 472-479.
10. Xianzhong Zhang, Zhengming Xiong, Yun Wu, Weibo Cai, Jeffery R. Tseng, Sanjiv S. Gambhir and Xiaoyuan Chen*. Quantitative PET imaging of tumor integrin V3 expression with [18F]FRGD2. J Nucl Med, 2006, 47:113-121.