该研究表明IL-2与IL-2Rα 的邻近共价结合选择性激活调节性T细胞并抑制自身免疫。该研究报道了一种策略，利用遗传密码扩增引导潜在的生物反应非天然氨基酸(FSY)合并到IL-2中，与IL-2Rα进行邻近共价结合，选择性地促进Treg激活。

期刊杂志：Signal Transduction and Targeted Therapy

影响因子：37.2

主要作者和团队成员：张博等

使用仪器：AKTA-pure，Octet (BLI)等

文章链接：

https://www.nature.com/articles/s41392-022-01208-3

其他支撑文章：

1. Proximity-enabled covalent binding of IL-2 to IL-2Rα selectively and persistently promotes Treg activation and suppresses autoimmunity. Signal Transduction and Targeted Therapy, 2022

2. Site-specific PEGylation of interleukin-2 enhances immunosuppression via the sustained activation of regulatory T cells, Nature biomedical engineering, 2021, 5(11): 1288-1305

3. Photoswitchable CAR-T Cell Function In Vitro and In Vivo via a Cleavable Mediator, Cell Chemical biology, 2021, 28(1): 60-69

4. In vitro elimination of autoreactive B cells from rheumatoid arthritis patients by universal chimeric antigen receptor T cells, Annals of the Rheumatic Diseases, 2021, 80(2): 176-184