Recently, Professor Huang Chaolan, Deputy Director of Medical Research Center, PUMCH, gave a lecture at the Xidan Campus titled “From Disease Mechanism to Diagnosis and Treatment Target - Biomarker-driven Precision Medicine Translation”.

Prof. Huang Chaolan elaborated on proteomics in terms of its definition, technology development, clinical application and clinical translation. According to her, “precision medicine” is not simply about “gene transcription and sequencing”, but revealing “diseases that are likely to occur, that show signs of occurring, that are occurring and that have already occurred” systemically from the perspective of “genomics - transcriptomics - proteomics - metabolomics”. Clinical biomarkers are a series of indicators of disease status. How to distill from existing abundant clinical samples verifiable and translatable clinical biomarkers so that “what comes from clinical settings goes back to clinical settings”? The answer lies in proteomics of clinical samples with high-level quality control and deep coverage.

For marker-driven translational medicine and clinical research, Prof. Huang Chaolan proposed three keys: first, a good clinical question and a cohort designed for the question; second, omics data subject to strict quality control; third, validation and reliable algorithms.

Huang Chaolan has long been dedicated to the development of new technologies and methods at the forefront of mass spectrometry and proteomics, and has over 20 years of experience of research and talent cultivation in this regard; she has published more than 90 papers in top international journals such as “Cell”, “Science” and “Nature”, with the total citation count exceeding 6,500.

Huang Chaolan said: “PUMCH has great clinicians as well as high-quality patient cohorts and clinical data, which is the source of and holds the key to real translations.”

Prof. Huang Chaolan was giving the lecture

Written by: General Office of Xidan Campus

Picture courtesy: General Office of Xidan Campus

Translator: Liu Haiyan

Editor: Wang Yao